The target of this radiocompound should be the capability of binding noradrenalin receptors as it happens with 123I-MIBG, but with a higher image quality and sensitivity granted by PET hardware. MIBG labeled with 124I, a positron emitting isotope suitable for PET imaging, got increased interest in clinical practice. The principal limitation of conventional nuclear medicine in neuroblastoma (mainly 123I-MIBG scan) is related to its relative low spatial resolution when compared with other radiological and functional techniques such as CT, MRI and PET, similarly to what happens in other pediatric tumors. Moreover, 123I-MIBG scan Is required when NB relapse is suspected and may establish the basis for the use of a targeted radionuclide therapy with 131I-MIBG. Many studies have been reported the important role of 123I-Meta-iodobenzylguanidine (MIBG) at the time of first staging and at the evaluation of treatment response, especially after induction chemotherapy. Bone and bone marrow metastases are quite common and, if present, result in a poor prognosis. Neuroblastoma (NB) is the most common extra-cranial solid tumor in pediatric patients and originates from sympathetic cells derived from the neural crest.
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